Can nanoparticles pass the blood brain barrier?
After getting into the body, nanoparticles will reach the organs through circulation. moreover, counting on their characteristics, like size, shape, and chemical reactivity, they will cross the barrier, or they will reach the brain through nerve fiber transport on the first cranial nerve. Nanoparticles square measure tiny sized (1-100 nm) particles derived from transition metals, silver, copper, aluminum, silicon, carbon and metal oxides that may simply cross the barrier (BBB) and/or turn out harm to the barrier integrity by sterilization epithelial tissue semipermeable membrane porousness. Our experimental and calculated results steered that the optimum size of nanoparticles for delivery into the brain via this mechanism would be five to six nm in our system. The blood–brain barrier restricts the passage of pathogens, the diffusion of solutes within the blood, and enormous or deliquescent molecules into the bodily fluid, whereas permitting the diffusion of hydrophobic molecules